Publications since 2025 by members of the Center, from PubMed, with Center members in bold. The list is refreshed from PubMed; the search combines Center faculty with a Philadelphia affiliation and papers that name the Kidney Innovation Center.
2026
Transcription factor TBX2 is a key regulator of vascular calcification
Li S, Liu H, Lee S, Ha E, Dumoulin B, Palmer MB, …, Susztak K
Eur Heart J 2026 · doi:10.1093/eurheartj/ehag756 · PubMed
Variation in Living Donor Evaluation and Acceptance across the United States
Amaral S, Copeland T, McCulloch CE, Weir MR, Ahearn P, Freedman BI, …, Ku E
Kidney360 2026 · doi:10.34067/KID.0000001400 · PubMed
Cardiovascular-kidney-metabolic syndrome as a mitochondrial systems disorder
Li S, Abel ED, Arany Z, Baur JA, Pei L, Susztak K
Nat Rev Nephrol 2026 · doi:10.1038/s41581-026-01127-4 · PubMed
Treatment burden, healthcare experiences, and health-related quality of life among youth with chronic kidney disease treated for hypertension
Botdorf M, Marchesani N, Ruebner R, Di Cocco E, Davies AJG, Hammond IS, …, Forrest CB
Qual Life Res 2026 · doi:10.1007/s11136-026-04401-x · PubMed
The Role of Angiopoietin-Like Proteins 3 and 4 and Their Target Lipases in CKD: A Drug-Target Mendelian Randomization Study
Yang G, Zhang DY, Fischman CJ, Cuchel M, Susztak K, Rader DJ
Am J Kidney Dis 2026 · doi:10.1053/j.ajkd.2026.06.015 · PubMed
Left ventricular remodeling by cardiac magnetic resonance in children with advanced chronic kidney disease: an analysis of the Chronic Kidney Disease in Children (CKiD) study
Reyes LZ, Roem J, Lang SM, Taylor MD, Warady BA, Furth SL, Mitsnefes M
Pediatr Nephrol 2026 · doi:10.1007/s00467-026-07538-6 · PubMed
The Ethics and Logistics of Control Arms in Nephrology Device Trials
Townsend RR
J Am Soc Nephrol 2026 · doi:10.1681/ASN.0000001277 · PubMed
Urinary YKL-40 as a diagnostic biomarker for cystinosis
Greenberg JH, Souza SD, Thiessen Philbrook HR, Obeid W, Rosenberg AZ, Levtchenko E, …, Parikh CR
JCI Insight 2026 · doi:10.1172/jci.insight.206193 · PubMed
Overlap Between Mandatory and Voluntary Value-Based Kidney Care Model Participation and Home Dialysis Use
Tummalapalli SL, Reddy YNV, Zhao Y, Bao Y, Zhu J, Navathe AS
JAMA Health Forum 2026 · doi:10.1001/jamahealthforum.2026.3046 · PubMed
Patient-reported ratings of transfer to adult care among young adults with chronic kidney disease
Richardson KL, Boyer B, Grzesek K, Pruette C, Johnson RJ, Furth SL, …,
Pediatr Nephrol 2026 · doi:10.1007/s00467-026-07486-1 · PubMed
Nucleic acid sensing pathways in kidney disease development
Andrade-Silva M, Kang C, Jang Y, Susztak K
Nat Rev Nephrol 2026 · doi:10.1038/s41581-026-01120-x · PubMed
Vitamin D Supplementation Associated With Alterations in Lipid Metabolism in Children With Glomerular Disease
Hasson DC, Surapaneni A, Melamed ML, Sethna CB, Atkinson MA, Zaritsky JJ, …, Denburg MR
Kidney Med 2026 · doi:10.1016/j.xkme.2026.101506 · PubMed
Stenosis in Mature Arteriovenous Fistulas Characterized by Contractile Smooth Muscle Cells and Versican
Zhang Y, Elzinad N, Lotfollahzadeh S, Lazowski A, Elsadawi M, Yin W, …, Chitalia VC
Kidney Int Rep 2026 · doi:10.1016/j.ekir.2026.106997 · PubMed
Accelerating Evidence-Based Practices in Acute Kidney Injury: A Consensus Statement from the XXXV ADQI Conference
Brown JR, Rewa OG, Rabin BA, Akcan-Arikan A, Awdishu L, Bagshaw SM, …, Neyra JA
Clin J Am Soc Nephrol 2026 · doi:10.2215/CJN.0000001205 · PubMed
Social determinants of health as predictors of latent symptom clusters in patients undergoing maintenance hemodialysis: A secondary analysis of the HOPE consortium randomized trial
Steel JL, Lockwood MB, Yabes JG, Hsu JY, Cavanaugh KL, Liebschutz JM, …,
J Pain 2026 · doi:10.1016/j.jpain.2026.106313 · PubMed
Advanced MRI methods for children and young adults with autosomal recessive polycystic kidney disease (ARPKD) to support future multi-center clinical trials
MacAskill CJ, Smothers JB, Kretzler ME, Heilman J, Pepin K, Kuehn B, …, Flask CA
Pediatr Radiol 2026 · doi:10.1007/s00247-026-06737-5 · PubMed
ELF3 links kidney function GWAS loci to maladaptive epithelial inflammation
Hou Y, Kloetzer K, Dumoulin B, Ha E, Liu H, Mukhi D, …, Susztak K
Sci Adv 2026 · doi:10.1126/sciadv.aec6741 · PubMed
Ambulatory arterial stiffness index among children and adolescents with chronic kidney disease: a report from the Chronic Kidney Disease in Children Study
Halbach SM, Roem J, Schneider MF, Samuels J, Furth SL, Warady BA, Flynn JT,
Pediatr Nephrol 2026 · doi:10.1007/s00467-026-07461-w · PubMed
Atlas of glomerular disease-specific genetic effects on blood transcriptome
Liu L, Wang C, Kravets O, Fermin D, Eichinger F, Zanoni F, …, Kiryluk K
medRxiv 2026 · doi:10.64898/2026.06.22.26356281 · PubMed
Real-World Long-term Comparisons of Rituximab versus Calcineurin Inhibitors for Membranous Nephropathy in the Cure Glomerulonephropathy Study
Gerety MK, Charu V, Simmons M, Seewald NJ, Glenn DA, Schaubel DE, …, Zee J
Kidney360 2026 · doi:10.34067/KID.0000001265 · PubMed
Natural History of C3 Glomerulopathy and Immune Complex-Associated Membranoproliferative Glomerulonephritis in Children
Dixon BP, Laskin BL, Goodwin Davies AJ, Razzaghi H, Maltenfort MG, Meloni S, …, Denburg MR
Clin J Am Soc Nephrol 2026 · doi:10.2215/CJN.0000001118 · PubMed
Meaningful Engagement of Patients in Research
McCowan P, Joseph T, Picataggio CB, Bailey L, Chandi S, Singh A, …, Flythe JE
Am J Kidney Dis 2026 · doi:10.1053/j.ajkd.2026.01.020 · PubMed
Cross-Modality Alignment of Spatial Transcriptomics, Multiplexed Imaging, and Histology with PHARAOH
Yao S, Jing Z, Jiang S, Li W, Yamamoto Y, Dumoulin B, …, Li M
Res Sq 2026 · doi:10.21203/rs.3.rs-9954002/v1 · PubMed
Three-Year Durability of Radiofrequency Renal Denervation: SPYRAL HTN-ON MED
Kandzari DE, Mahfoud F, Townsend RR, Kario K, Weber MA, Schmieder RE, …, Böhm M
J Am Heart Assoc 2026 · doi:10.1161/JAHA.126.049081 · PubMed
Reimagining Value-Based Kidney Care: What Lies Beyond the Advancing American Kidney Health Initiative?
Ahmed U, Godwin CJ, Shah A, Reddy YNV
Kidney360 2026 · doi:10.34067/KID.0000001286 · PubMed
Acute Care Visits and Subsequent Health-Related Quality of Life among Children and Adults with Glomerular Disease in the Cure Glomerulonephropathy Cohort
Yang CW, Ramachandra SS, Liu Q, Glenn DA, Denburg M, Miano T, Zee J
Glomerular Dis 2026 · doi:10.1159/000552975 · PubMed
A Cooking Camp for Children with Kidney Disease: Recipe for Resilience
Amaral S
Clin J Am Soc Nephrol 2026 · doi:10.2215/CJN.0000001137 · PubMed
Robust footprinting with sample-specific Tn5 bias correction for bulk and single cell ATAC-seq
Lin Y, Wang H, Wilson PC, Zhang NR
Nat Commun 2026 · doi:10.1038/s41467-026-73164-3 · PubMed
Beyond biological risk: socioeconomic vulnerability and adverse pediatric kidney transplant outcomes
Kizilbash S, Wi CI, Amaral S, Beenken M, Watson D, McKinney W, Juhn Y
Pediatr Nephrol 2026 · doi:10.1007/s00467-026-07322-6 · PubMed
Bile acid metabolites and carotid intima media thickness in the Chronic Kidney Disease in Children (CKiD) study
Lee AM, Mitsnefes MM, Roem J, Warady BA, Furth SL, Denburg MR,
Pediatr Nephrol 2026 · doi:10.1007/s00467-026-07343-1 · PubMed
Physical Function Decline Among Adults With Moderate-to-Severe CKD
Schrauben SJ, Brown R, Shlipak MG, Tangri N, Zhang X, Nair D, …,
Kidney Int Rep 2026 · doi:10.1016/j.ekir.2026.106584 · PubMed
Blood Pressure Control in Adolescents With CKD and Risk of Kidney Failure in Young Adulthood
Glenn DA, Botdorf M, Allen A, Dickinson K, Wieand K, Davies AG, …, Zee J
Kidney Med 2026 · doi:10.1016/j.xkme.2026.101388 · PubMed
Cluster Randomized Controlled Trial of Intensive Systolic Blood Pressure Control in Patients With Renal Cell or Thyroid Cancer Receiving VEGFR Tyrosine Kinase Inhibitors: ECOG-ACRIN EAQ191
Ky B, Liu T, Margulies KB, Mitchell JD, Haas NB, Gareen IF, …, Wagner LI
Hypertension 2026 · doi:10.1161/HYPERTENSIONAHA.125.26016 · PubMed
Allocation of Kidney Allografts From Donors With Kidney Donor Profile Index <35% and the Impact of Kidney Donor Profile Index Revisions on Access to Transplantation for Children
Sonnenberg EM, Amaral S, Zhang S, Rubin J, Levine MH, Potluri VS
Am J Kidney Dis 2026 · doi:10.1053/j.ajkd.2026.02.643 · PubMed
The Design and Conduct of Cohort Studies of Peoples With CKD - International Perspectives From iNET-CKD
Alencar de Pinho N, Dember LM, Hirakawa Y, Imaizumi T, Jha V, Levin A, …,
Kidney Int Rep 2026 · doi:10.1016/j.ekir.2026.106540 · PubMed
ACLY-Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation-Associated Fibrosis in Chronic Kidney Disease
Du C, Mukhi D, Li L, Li C, Pan S, Dumoulin B, …, Susztak K
Adv Sci (Weinh) 2026 · doi:10.1002/advs.75247 · PubMed
HNF1B integrates signals in a feed-forward loop driving kidney disease progression
Isnard P, Makinistoglu MP, Leibovici M, Levinsohn J, Zimmermann N, Cohen C, …, Pontoglio M
Science 2026 · doi:10.1126/science.aea3219 · PubMed
The epidemiology of kidney and urinary tract infections in pediatric chronic kidney disease: prevalence, risk factors and association with GFR decline in the Chronic Kidney Disease in Children Study
Ng DK, Molino AR, Zhang S, Stonebrook EJ, Wong CS, Gyawali P, …,
Pediatr Nephrol 2026 · doi:10.1007/s00467-026-07253-2 · PubMed
Multiscale confidence quantification for virtual spatial transcriptomics with UTOPIA
Jin K, Chen Z, Yu X, Yuan M, Schroeder A, Dumoulin B, …, Li M
bioRxiv 2026 · doi:10.64898/2026.03.01.708850 · PubMed
Platform-dependent effects of genetic variants on plasma APOL1
Wang QS, Huang J, Chan LJG, Haste N, Olsson N, Gaun A, …, Baryshnikova A
iScience 2026 · doi:10.1016/j.isci.2026.114953 · PubMed
Pixel2Gene enables histology-guided reconstruction and prediction of spatial gene expression
Yao S, Schroeder A, Jiang S, Im S, Park JH, Dumoulin B, …, Li M
bioRxiv 2026 · doi:10.64898/2026.02.21.707168 · PubMed
Single-Cell Resolution Drug Effects of Renin-Angiotensin-Aldosterone Blockade in ZSF1 Rat Diabetic Kidney Disease
Balzer MS, Zhou J, Abedini A, Ma Z, Hou Y, Yadav T, …, Susztak K
J Am Soc Nephrol 2026 · doi:10.1681/ASN.0000000995 · PubMed
Renin-Angiotensin-Aldosterone System Inhibition in Pediatric Chronic Kidney Disease-Reply
Denburg MR, Zee J, Forrest CB
JAMA Pediatr 2026 · doi:10.1001/jamapediatrics.2026.2885 · PubMed
2025
Cell-Specific Inducible HumanRisk Variant Expression in Mice Causes Hypertension and Renal Damage
Li F, Poudel B, Andrade-Silva M, Wu J, Raman A, Cruz-Morales E, …, Susztak K
Circulation 2025 · doi:10.1161/CIRCULATIONAHA.124.071351 · PubMed
Multi-omics analysis identifies S100a10/Anxa2 complex within proximal tubule aggravates acute kidney injury through p-Stat3/Spp1 signaling
Chen Z, Ye L, Zhu M, Lin X, Wu J, Zhang X, …, Chen H
Transl Res 2025 · doi:10.1016/j.trsl.2025.11.003 · PubMed
Spatial metabolomics and multiomics integration for breakthroughs in precision medicine for kidney disease
Sharma K, Hansen J, Susztak K, Eberlin L, Anderton CR, Alexandrov T, Iyengar R
Nat Rev Nephrol 2025 · doi:10.1038/s41581-025-01007-3 · PubMed
Exome-Wide Analysis Identifies a RareMissense Variant Associated With Diabetic Kidney Disease
Sandholm N, Cole JB, Nair V, Brennan E, Giardini E, Haukka JK, …,
Kidney Int Rep 2025 · doi:10.1016/j.ekir.2025.09.053 · PubMed
Mechanisms of diabetic kidney disease and established and emerging treatments
Martinez Leon V, Hilburg R, Susztak K
Nat Rev Endocrinol 2025 · doi:10.1038/s41574-025-01171-3 · PubMed
The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health
Hirohama D, Fadista J, Ha E, Liu H, Abedini A, Levinsohn J, …, Susztak K
Nat Med 2025 · doi:10.1038/s41591-025-03872-8 · PubMed
Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas
Klötzer KA, Abedini A, Li S, Balzer MS, Liang X, Levinsohn J, …, Susztak K
Nat Genet 2025 · doi:10.1038/s41588-025-02285-0 · PubMed
Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci
Cole JB, Dahlström EH, Fermin D, Gupta Y, Hill C, Smyth LJ, …, Hirschhorn JN
J Am Soc Nephrol 2025 · doi:10.1681/ASN.0000000718 · PubMed
Platform-dependent effects of genetic variants on plasma APOL1
Wang QS, Huang J, Chan L, Haste N, Olsson N, Gaun A, …, Baryshnikova A
bioRxiv 2025 · doi:10.1101/2025.01.30.635763 · PubMed
CHAC1 increases kidney disease risk by modulating ferroptosis
Kolligundla LP, Sullivan KM, Mukhi D, Andrade-Silva M, Liu H, Guan Y, …, Susztak K
Sci Transl Med 2025 · doi:10.1126/scitranslmed.adn3079 · PubMed
The actin and microtubule network regulator WHAMM is identified as a key kidney disease risk gene
Mukhi D, Kolligundla LP, Doke T, Silva MA, Liu H, Palmer M, Susztak K
Cell Rep 2025 · doi:10.1016/j.celrep.2025.115462 · PubMed
SNA-modified antisense oligonucleotides: A new pathway for renal targeting?
Dumoulin B, Yamada K, Susztak K
Mol Ther Nucleic Acids 2025 · doi:10.1016/j.omtn.2025.102476 · PubMed